In Silico Identification of Highly Conserved Epitopes of Influenza A H1N1, H2N2, H3N2, and H5N1 with Diagnostic and Vaccination Potential
Identifieur interne : 000607 ( Main/Exploration ); précédent : 000606; suivant : 000608In Silico Identification of Highly Conserved Epitopes of Influenza A H1N1, H2N2, H3N2, and H5N1 with Diagnostic and Vaccination Potential
Auteurs : José Esteban Mu Oz-Medina [Mexique] ; Carlos Javier Sánchez-Vallejo [Mexique] ; Alfonso Méndez-Tenorio [Mexique] ; Irma Eloísa Monroy-Mu Oz [Mexique] ; Javier Angeles-Martínez [Mexique] ; Andrea Santos Coy-Arechavaleta [Mexique] ; Clara Esperanza Santacruz-Tinoco [Mexique] ; Joaquín González-Ibarra [Mexique] ; Yu-Mei Anguiano-Hernández [Mexique] ; César Raúl González-Bonilla [Mexique] ; Eva Ram N-Gallegos [Mexique] ; José Alberto Díaz-Qui Onez [Mexique]Source :
- BioMed Research International [ 2314-6133 ] ; 2015.
Descripteurs français
- KwdFr :
- Humains, Simulation numérique, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Épitopes (génétique), Épitopes (immunologie).
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Épitopes.
- immunologie : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Épitopes.
- Humains, Simulation numérique.
English descriptors
- KwdEn :
- Computer Simulation, Epitopes (genetics), Epitopes (immunology), Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology).
- MESH :
- chemical , genetics : Epitopes, Influenza Vaccines.
- chemical , immunology : Epitopes, Influenza Vaccines.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype.
- Computer Simulation, Humans.
Abstract
The unpredictable, evolutionary nature of the influenza A virus (IAV) is the primary problem when generating a vaccine and when designing diagnostic strategies; thus, it is necessary to determine the constant regions in viral proteins. In this study, we completed an
Url:
DOI: 10.1155/2015/813047
PubMed: 26346523
PubMed Central: 4544958
Affiliations:
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Sección XVI, Delegación Tlalpan, 14080 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Genómica, Departamento de Biología Molecular, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Colonia Sección XVI, Delegación Tlalpan, 14080 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Santos Coy Arechavaleta, Andrea" sort="Santos Coy Arechavaleta, Andrea" uniqKey="Santos Coy Arechavaleta A" first="Andrea" last="Santos Coy-Arechavaleta">Andrea Santos Coy-Arechavaleta</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Santacruz Tinoco, Clara Esperanza" sort="Santacruz Tinoco, Clara Esperanza" uniqKey="Santacruz Tinoco C" first="Clara Esperanza" last="Santacruz-Tinoco">Clara Esperanza Santacruz-Tinoco</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Ibarra, Joaquin" sort="Gonzalez Ibarra, Joaquin" uniqKey="Gonzalez Ibarra J" first="Joaquín" last="González-Ibarra">Joaquín González-Ibarra</name><affiliation wicri:level="1"><nlm:aff id="I5">División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Anguiano Hernandez, Yu Mei" sort="Anguiano Hernandez, Yu Mei" uniqKey="Anguiano Hernandez Y" first="Yu-Mei" last="Anguiano-Hernández">Yu-Mei Anguiano-Hernández</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Bonilla, Cesar Raul" sort="Gonzalez Bonilla, Cesar Raul" uniqKey="Gonzalez Bonilla C" first="César Raúl" last="González-Bonilla">César Raúl González-Bonilla</name><affiliation wicri:level="1"><nlm:aff id="I5">División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Ram N Gallegos, Eva" sort="Ram N Gallegos, Eva" uniqKey="Ram N Gallegos E" first="Eva" last="Ram N-Gallegos">Eva Ram N-Gallegos</name><affiliation wicri:level="1"><nlm:aff id="I6">Laboratorio de Citopatologia Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas Campus Zacatenco, Instituto Politécnico Nacional, Wilfrido Massieu S/N, Colonia Nueva Industrial Vallejo, Delegación Gustavo A. Madero, 07738 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Citopatologia Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas Campus Zacatenco, Instituto Politécnico Nacional, Wilfrido Massieu S/N, Colonia Nueva Industrial Vallejo, Delegación Gustavo A. Madero, 07738 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Qui Onez, Jose Alberto" sort="Diaz Qui Onez, Jose Alberto" uniqKey="Diaz Qui Onez J" first="José Alberto" last="Díaz-Qui Onez">José Alberto Díaz-Qui Onez</name><affiliation wicri:level="1"><nlm:aff id="I7">Instituto de Diagnóstico y Referencia Epidemiológicos “Manuel Martínez Báez”, Francisco de P. Miranda No. 177, Colonia Unidad Lomas de Plateros, Delegación Álvaro Obregón, 01480 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Diagnóstico y Referencia Epidemiológicos “Manuel Martínez Báez”, Francisco de P. Miranda No. 177, Colonia Unidad Lomas de Plateros, Delegación Álvaro Obregón, 01480 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I8">Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Colonia Copilco Universidad, Delegación Coyoacán, 04510 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Colonia Copilco Universidad, Delegación Coyoacán, 04510 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26346523</idno><idno type="pmc">4544958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544958</idno><idno type="RBID">PMC:4544958</idno><idno type="doi">10.1155/2015/813047</idno><date when="2015">2015</date><idno 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xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Vallejo, Carlos Javier" sort="Sanchez Vallejo, Carlos Javier" uniqKey="Sanchez Vallejo C" first="Carlos Javier" last="Sánchez-Vallejo">Carlos Javier Sánchez-Vallejo</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Colonia Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Colonia Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Mendez Tenorio, Alfonso" sort="Mendez Tenorio, Alfonso" uniqKey="Mendez Tenorio A" first="Alfonso" last="Méndez-Tenorio">Alfonso Méndez-Tenorio</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Colonia Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Colonia Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Monroy Mu Oz, Irma Eloisa" sort="Monroy Mu Oz, Irma Eloisa" uniqKey="Monroy Mu Oz I" first="Irma Eloísa" last="Monroy-Mu Oz">Irma Eloísa Monroy-Mu Oz</name><affiliation wicri:level="1"><nlm:aff id="I3">Laboratorio de Genómica, Departamento de Genética y Genómica Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Montes Urales 800, Colonia Lomas Virreyes, Delegación Miguel Hidalgo, 11000 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Genómica, Departamento de Genética y Genómica Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Montes Urales 800, Colonia Lomas Virreyes, Delegación Miguel Hidalgo, 11000 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Angeles Martinez, Javier" sort="Angeles Martinez, Javier" uniqKey="Angeles Martinez J" first="Javier" last="Angeles-Martínez">Javier Angeles-Martínez</name><affiliation wicri:level="1"><nlm:aff id="I4">Laboratorio de Genómica, Departamento de Biología Molecular, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Colonia Sección XVI, Delegación Tlalpan, 14080 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Genómica, Departamento de Biología Molecular, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Colonia Sección XVI, Delegación Tlalpan, 14080 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Santos Coy Arechavaleta, Andrea" sort="Santos Coy Arechavaleta, Andrea" uniqKey="Santos Coy Arechavaleta A" first="Andrea" last="Santos Coy-Arechavaleta">Andrea Santos Coy-Arechavaleta</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Santacruz Tinoco, Clara Esperanza" sort="Santacruz Tinoco, Clara Esperanza" uniqKey="Santacruz Tinoco C" first="Clara Esperanza" last="Santacruz-Tinoco">Clara Esperanza Santacruz-Tinoco</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Ibarra, Joaquin" sort="Gonzalez Ibarra, Joaquin" uniqKey="Gonzalez Ibarra J" first="Joaquín" last="González-Ibarra">Joaquín González-Ibarra</name><affiliation wicri:level="1"><nlm:aff id="I5">División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Anguiano Hernandez, Yu Mei" sort="Anguiano Hernandez, Yu Mei" uniqKey="Anguiano Hernandez Y" first="Yu-Mei" last="Anguiano-Hernández">Yu-Mei Anguiano-Hernández</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio Central de Epidemiología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Avenida Jacarandas S/N, Esquina Circuito Interior, Colonia La Raza Delegación Azcapotzalco, 02990 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Bonilla, Cesar Raul" sort="Gonzalez Bonilla, Cesar Raul" uniqKey="Gonzalez Bonilla C" first="César Raúl" last="González-Bonilla">César Raúl González-Bonilla</name><affiliation wicri:level="1"><nlm:aff id="I5">División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Colonia Del Valle, Delegación Benito Juárez, 03100 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Ram N Gallegos, Eva" sort="Ram N Gallegos, Eva" uniqKey="Ram N Gallegos E" first="Eva" last="Ram N-Gallegos">Eva Ram N-Gallegos</name><affiliation wicri:level="1"><nlm:aff id="I6">Laboratorio de Citopatologia Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas Campus Zacatenco, Instituto Politécnico Nacional, Wilfrido Massieu S/N, Colonia Nueva Industrial Vallejo, Delegación Gustavo A. Madero, 07738 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Citopatologia Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas Campus Zacatenco, Instituto Politécnico Nacional, Wilfrido Massieu S/N, Colonia Nueva Industrial Vallejo, Delegación Gustavo A. Madero, 07738 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Qui Onez, Jose Alberto" sort="Diaz Qui Onez, Jose Alberto" uniqKey="Diaz Qui Onez J" first="José Alberto" last="Díaz-Qui Onez">José Alberto Díaz-Qui Onez</name><affiliation wicri:level="1"><nlm:aff id="I7">Instituto de Diagnóstico y Referencia Epidemiológicos “Manuel Martínez Báez”, Francisco de P. Miranda No. 177, Colonia Unidad Lomas de Plateros, Delegación Álvaro Obregón, 01480 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Diagnóstico y Referencia Epidemiológicos “Manuel Martínez Báez”, Francisco de P. Miranda No. 177, Colonia Unidad Lomas de Plateros, Delegación Álvaro Obregón, 01480 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I8">Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Colonia Copilco Universidad, Delegación Coyoacán, 04510 México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Colonia Copilco Universidad, Delegación Coyoacán, 04510 México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Epitopes (genetics)</term><term>Epitopes (immunology)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Simulation numérique</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (génétique)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Épitopes (génétique)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Simulation numérique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The unpredictable, evolutionary nature of the influenza A virus (IAV) is the primary problem when generating a vaccine and when designing diagnostic strategies; thus, it is necessary to determine the constant regions in viral proteins. In this study, we completed an <italic>in silico</italic> analysis of the reported epitopes of the 4 IAV proteins that are antigenically most significant (HA, NA, NP, and M2) in the 3 strains with the greatest world circulation in the last century (H1N1, H2N2, and H3N2) and in one of the main aviary subtypes responsible for zoonosis (H5N1). For this purpose, the HMMER program was used to align 3,016 epitopes reported in the Immune Epitope Database and Analysis Resource (IEDB) and distributed in 34,294 stored sequences in the Pfam database. Eighteen epitopes were identified: 8 in HA, 5 in NA, 3 in NP, and 2 in M2. These epitopes have remained constant since they were first identified (~91 years) and are present in strains that have circulated on 5 continents. 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Serohijos</name></author><author><name sortKey="Choi, J M" uniqKey="Choi J">J.-M. Choi</name></author><author><name sortKey="Shakhnovich, E I" uniqKey="Shakhnovich E">E. I. Shakhnovich</name></author><author><name sortKey="Pekosz, A" uniqKey="Pekosz A">A. Pekosz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Mu Oz Medina, Jose Esteban" sort="Mu Oz Medina, Jose Esteban" uniqKey="Mu Oz Medina J" first="José Esteban" last="Mu Oz-Medina">José Esteban Mu Oz-Medina</name></noRegion><name sortKey="Angeles Martinez, Javier" sort="Angeles Martinez, Javier" uniqKey="Angeles Martinez J" first="Javier" last="Angeles-Martínez">Javier Angeles-Martínez</name><name sortKey="Anguiano Hernandez, Yu Mei" sort="Anguiano Hernandez, Yu Mei" uniqKey="Anguiano Hernandez Y" first="Yu-Mei" last="Anguiano-Hernández">Yu-Mei Anguiano-Hernández</name><name sortKey="Diaz Qui Onez, Jose Alberto" sort="Diaz Qui Onez, Jose Alberto" uniqKey="Diaz Qui Onez J" first="José Alberto" last="Díaz-Qui Onez">José Alberto Díaz-Qui Onez</name><name sortKey="Diaz Qui Onez, Jose Alberto" sort="Diaz Qui Onez, Jose Alberto" uniqKey="Diaz Qui Onez J" first="José Alberto" last="Díaz-Qui Onez">José Alberto Díaz-Qui Onez</name><name sortKey="Gonzalez Bonilla, Cesar Raul" sort="Gonzalez Bonilla, Cesar Raul" uniqKey="Gonzalez Bonilla C" first="César Raúl" last="González-Bonilla">César Raúl González-Bonilla</name><name sortKey="Gonzalez Ibarra, Joaquin" sort="Gonzalez Ibarra, Joaquin" uniqKey="Gonzalez Ibarra J" first="Joaquín" last="González-Ibarra">Joaquín González-Ibarra</name><name sortKey="Mendez Tenorio, Alfonso" sort="Mendez Tenorio, Alfonso" uniqKey="Mendez Tenorio A" first="Alfonso" last="Méndez-Tenorio">Alfonso Méndez-Tenorio</name><name sortKey="Monroy Mu Oz, Irma Eloisa" sort="Monroy Mu Oz, Irma Eloisa" uniqKey="Monroy Mu Oz I" first="Irma Eloísa" last="Monroy-Mu Oz">Irma Eloísa Monroy-Mu Oz</name><name sortKey="Ram N Gallegos, Eva" sort="Ram N Gallegos, Eva" uniqKey="Ram N Gallegos E" first="Eva" last="Ram N-Gallegos">Eva Ram N-Gallegos</name><name sortKey="Sanchez Vallejo, Carlos Javier" sort="Sanchez Vallejo, Carlos Javier" uniqKey="Sanchez Vallejo C" first="Carlos Javier" last="Sánchez-Vallejo">Carlos Javier Sánchez-Vallejo</name><name sortKey="Santacruz Tinoco, Clara Esperanza" sort="Santacruz Tinoco, Clara Esperanza" uniqKey="Santacruz Tinoco C" first="Clara Esperanza" last="Santacruz-Tinoco">Clara Esperanza Santacruz-Tinoco</name><name sortKey="Santos Coy Arechavaleta, Andrea" sort="Santos Coy Arechavaleta, Andrea" uniqKey="Santos Coy Arechavaleta A" first="Andrea" last="Santos Coy-Arechavaleta">Andrea Santos Coy-Arechavaleta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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